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On March 9, at the American College of Cardiology Scientific Sessions in New Orleans, investigators presented details of their studies with rimonabant (trade name: Acomplia) – the first of a new class of drugs (selective CB1 blockers) aimed at helping with weight loss and smoking cessation. CB1 blockers act on the endocannabinoid system (the EC system), a natural system that modulates the body’s energy balance and nicotine dependence. An over-stimulated EC system is thought to play a role in obesity and in tobacco dependence, and CB1 blockers are supposed to reduce this overstimulation. In a press release 3 weeks ago, the makers of rimonabant (Sanofi-Synthelabo,) indicated that the studies were favorable.

Data from two studies with rimonabant were reported this week. In the first, called the Stratus-US study, the drug’s effect on smoking cessation was evaluated. In this study, 787 smokers (average of 23 cigarettes per day) were randomized to receive either placebo, or rimonabant in doses of either 5 mg or 20 mg per day. The patients received the study drugs for 10 weeks. They were permitted to continue smoking for the first 2 weeks, but were instructed to attempt to quit smoking on Day 15. The number of patients who had not smoked during the last 4 weeks of the 10 week period were tabulated. Of patients who took 20 mg of rimonabant, 36% had quit smoking. Of patients who took either placebo or 5 mg rimonabant, only 20% successfully quit. Further, of those patients who quit smoking, the ones taking either placebo or 5 mg rimonabant gained 84% more weight than those taking 20 mg rimonabant. Thus, rimonabant at 20 mg per day significantly increased the rate of successfully quitting smoking, and also greatly reduced post-smoking-cessation weight gain.

In the second study (the RIO-Lipids study,) 1036 patients who were either overweight or obese and who had blood lipid disorderswere also randomized to one of three groups (placebo vs. 5 mg/day or 20 mg/day rimonabant). After 1 year of treatment, patients receiving 20 mg rimonabant lost an average of about 20 pounds of weight, compared to 5 pounds for patients on placebo. Further, patients receiving 20 mg rimonabant had significant improvements (compared to placebo) in waist circumference, HDL levels, triglyceride levels, CRP levels, and insulin sensitivity. For patients with metabolic syndrome at baseline (which included about 50% of the study population), half of those taking 20 mg rimonabant no longer had metabolic syndromeat the end of the study.

At times it may take longer to produce visible results but with a good weight loss product you are sure to have results.
Today, there are a lot of diet pills that are said to be the best weight loss products and also claiming to be the most effective diet pills that were out in the market nowadays.
The weight loss products without proven records are bound to take you nowhere in your journey to lose extra weight in your body.
The natural weight loss products take more time but do not have any side effects.
There are many weight loss products in the market today in the form of diet supplements, diet plans and exercise machines.

Smartness of an individual can only be gauzed by the action he or she takes to get out of a problem. Whatever may be the complexity of such a problem, only a smart individual can get out of it with flying colours. Obesity is one such problem which is really complex. It needs a lot or determination, willpower and patience if someone is thinking to get out of it. Even individuals who are smart in other spheres of life come to their wits end, to get out of obesity.

Obesity can result from excessive intake of food, lack of physical activities, lack of knowledge on balanced diet and genetic factors etc. Obesity can also be visible as a result of side effect of some certain kind of medications. Obesity is considered as a disease by the medical fraternity as it may give rise to future health risks like – heart ailments, diabetes, prostate cancer, high blood pressure, and hypertension etc. Hence, it is important to get rid of obesity when time is left.

Acomplia is a diet pill is a sympathomimetic amine and is known as �anorexigenic’ or �anorectic’ drug too. This diet pill stimulates the central nervous system and its periphery thus helps in increasing heart rate and blood pressure. This increase in blood pressure and heart rate helps one decrease his or her appetite. Acomplia is a short term appetite suppressant to be used in tandem with controlled diet and exercises. As Acomplia is a diet supplement it cannot directly help one get out of obesity rather it helps in supplementing the process of weight loss through exercises.